McIntyre D C
Physiol Behav. 1979 Nov;23(5):855-9. doi: 10.1016/0031-9384(79)90190-2.
Kindling of the anterior neocortex (AC) was shown to produce a brief focal motor seizure, characterized by a clonic-tonic-clonic response of the forelimbs with the animal in a prone posture. These same brief seizures, as previously reported, did not produce retrograde amnesia in a CER paradigm. With repeated evocations, over several days, the AC convulsions exhibited a dramatic increase of the second clonic phase (generalized) and came to appear similar to amygdala kindled convulsions. These generalized AC convulsions, like briefly kindled amygdala convulsions, produced good retrograde amnesia for a CER. With extensive amygdala kindling prior to CER training, a severe CER acquisition deficit was observed. These latter as well as other data suggest that protracted amygdala kindling produces a subsequent reduced ability to acquire fear motivated responses.
研究表明，前新皮质（AC）点燃会引发短暂的局灶性运动性癫痫发作，其特征是动物处于俯卧姿势时前肢出现阵挛 - 强直 - 阵挛反应。如先前报道，这些相同的短暂癫痫发作在条件性情绪反应（CER）范式中不会产生逆行性遗忘。在几天内反复诱发后，AC惊厥的第二个阵挛期（全身性）显著增加，并且开始类似于杏仁核点燃惊厥。这些全身性AC惊厥，就像短暂点燃的杏仁核惊厥一样，在CER中产生了良好的逆行性遗忘。在CER训练之前进行广泛的杏仁核点燃时，观察到严重的CER习得缺陷。这些以及其他数据表明，长期的杏仁核点燃会导致随后获得恐惧动机反应的能力下降。
