Zeineh R A
Res Commun Chem Pathol Pharmacol. 1979 Nov;26(2):347-56.
The metabolism of transferrin was studied in 17 selected burned patients. Transferrin metabolism also was studied in 5 of the patients after healing. The concentration of plasma transferrin in burned patients, measured by radial immunodiffusion, was reduced to 300 mg% for the first week following injury. Thereafter it rose steadily reaching the normal concentration of 350-360 mg% 35 days after injury. Traces of transferrin were present in urine a week after injury. Transferrin was labeled by injecting 14C-glucosamine intravenously following injury and again after healing was complete. Labeled transferrin was isolated from serum by specific immunoprecipitation. The specific activity of transferrin reached a peak 3-6 hr after injury and 9-12 hr after healing. The half-life time was 4.5 days during injury and 9.6 days after healing. The data indicated that both synthesis and catabolism of transferrin were accelerated in injury.
对17例选定的烧伤患者的转铁蛋白代谢进行了研究。还对其中5例患者愈合后的转铁蛋白代谢进行了研究。通过放射免疫扩散法测定，烧伤患者血浆转铁蛋白浓度在受伤后的第一周降至300mg%。此后，它稳步上升，在受伤后35天达到350 - 360mg%的正常浓度。受伤一周后，尿液中出现微量转铁蛋白。受伤后及愈合完成后，通过静脉注射14C - 葡糖胺对转铁蛋白进行标记。通过特异性免疫沉淀从血清中分离出标记的转铁蛋白。转铁蛋白的比活性在受伤后3 - 6小时和愈合后9 - 12小时达到峰值。受伤期间半衰期为4.5天，愈合后为9.6天。数据表明，受伤时转铁蛋白的合成和分解代谢均加速。
