Lykkelund C, Lund E D
Scand J Clin Lab Invest. 1979 Apr;39(2):151-7. doi: 10.3109/00365517909106087.
A decreased plasma glucagon response to insulin-induced hypoglycaemia was found in the normoglucagonaemic alloxan diabetic rat. 0.021-0.240 ng/ml was accepted as the range of normoglucagonaemia. The reduction of the glucagon response was not due to destruction of the alpha 2-cells by alloxan, since a normal response to arginine could be demonstrated. The decreased glucagon response to hypoglycaemia in the insulin deficient normoglucagonaemic alloxan diabetic rat suggests that this alpha 2-cell dysfunction may be caused by insulin lack.
在血糖正常的四氧嘧啶糖尿病大鼠中，发现血浆胰高血糖素对胰岛素诱导的低血糖反应降低。0.021 - 0.240 ng/ml被认为是血糖正常的范围。胰高血糖素反应的降低并非由于四氧嘧啶对α2细胞的破坏，因为对精氨酸的正常反应可以得到证实。胰岛素缺乏的血糖正常的四氧嘧啶糖尿病大鼠对低血糖的胰高血糖素反应降低表明，这种α2细胞功能障碍可能是由胰岛素缺乏引起的。
