Patel D G
Metabolism. 1983 Apr;32(4):377-82. doi: 10.1016/0026-0495(83)90047-1.
The role of prolonged insulin treatment of diabetic rats on the lack of glucagon and catecholamine increases in response to insulin-hypoglycemia was investigated. Streptozotocin diabetic rats were maintained in a normoglycemic state for a long period by intraperitoneal constant infusion of insulin with the Alzet osmotic minipumps. Hyperglucagonemia observed in diabetic rats was normalized with insulin treatment. However, the blunted response of glucagon during insulin-hypoglycemia was not altered with insulin treatment. On the other hand, in diabetic rats the diminished catecholamine response to insulin-induced hypoglycemia was rendered normal after insulin treatment. The data indicate that the lack of glucagon and catecholamine responses in diabetic rats in response to insulin-hypoglycemia can vary independently. The persistent decreased glucagon response in normoglycemic diabetics could be the cause of their impaired recovery from hypoglycemia.
研究了对糖尿病大鼠进行长期胰岛素治疗，对其缺乏胰高血糖素和儿茶酚胺因胰岛素低血糖而增加的影响。通过使用Alzet渗透微型泵腹腔内持续输注胰岛素，将链脲佐菌素糖尿病大鼠长期维持在正常血糖状态。糖尿病大鼠中观察到的高胰高血糖素血症通过胰岛素治疗恢复正常。然而，胰岛素低血糖期间胰高血糖素反应迟钝并未因胰岛素治疗而改变。另一方面，糖尿病大鼠中儿茶酚胺对胰岛素诱导的低血糖反应减弱在胰岛素治疗后恢复正常。数据表明，糖尿病大鼠对胰岛素低血糖的胰高血糖素和儿茶酚胺反应缺乏可能独立变化。血糖正常的糖尿病患者中持续降低的胰高血糖素反应可能是其低血糖恢复受损的原因。
