Keough E M, Wood B G
Tissue Cell. 1979;11(4):773-80. doi: 10.1016/0040-8166(79)90030-2.
Little (lit) is a single gene dwarf mutation described in the C57Bl/6J strain of laboratory mouse. This study was designed to determine the effect of the mutation little on mammary gland development during pregnancy and post-partum periods. Failure of mutant females to lactate at first parturition appears to be due to the endocrine environment of the gland rather than any intrinsic defect of the mammary epithelium. Treatment of primiparous lit/lit females with exogenous growth hormone or prolactin resulted in lactogenesis. Treatment with hydrocortisone resulted in increased amounts of organized rough endoplasmic reticulum but lactation did not occur.
矮小（lit）是在实验室小鼠C57Bl/6J品系中描述的单基因侏儒突变。本研究旨在确定矮小突变对妊娠和产后乳腺发育的影响。突变雌性在首次分娩时无法泌乳似乎是由于腺体的内分泌环境，而非乳腺上皮的任何内在缺陷。用外源性生长激素或催乳素治疗初产lit/lit雌性可导致泌乳。用氢化可的松治疗可使有组织的粗面内质网数量增加，但未发生泌乳。
