O'Brien M D
Stroke. 1979 Nov-Dec;10(6):623-8. doi: 10.1161/01.str.10.6.623.
The genesis of ischemic cerebral edema is multi-factorial and the relative importance of these many factors varies throughout the lesion and with time. The initial event is intracellular edema which may be followed by extracellular edema. This situation precludes any simple treatment, particularly because the favorable alteration of one factor might be detrimental to another.
缺血性脑水肿的成因是多因素的，这些众多因素的相对重要性在整个病变过程中以及随时间而变化。最初的事件是细胞内水肿，随后可能会出现细胞外水肿。这种情况排除了任何简单的治疗方法，特别是因为一个因素的有利改变可能对另一个因素有害。
