Cerebrospinal fluid circulation, cerebral edema, and intracranial pressure.

Cerebrospinal fluid (CSF) circulation plays an important role in acute and chronic disorders of the central nervous system. Correction of impaired CSF circulation by medical or surgical means carries important risks as well as lifesaving benefits. CSF circulation is intimately associated with intracranial pressure, cerebral edema, cerebral perfusion pressure, and cerebral blood flow. Clinical and experimental aspects of the CSF circulation are examined to provide insight into the often subtle physiological interactions that must be considered when treating patients with altered CSF circulation.