关于抗体分子活性位点的位置和结构 - Suppr

Suppr

超能文献

On the location and structure of the active sites of antibody molecules.

作者信息

Singer S J, Thorpe N O

出版信息

Proc Natl Acad Sci U S A. 1968 Aug;60(4):1371-8. doi: 10.1073/pnas.60.4.1371.

DOI:10.1073/pnas.60.4.1371

PMID:5244745

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC224928/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b4f/224928/94de28af9736/pnas00122-0324-a.jpg

相似文献

On the location and structure of the active sites of antibody molecules.关于抗体分子活性位点的位置和结构

Proc Natl Acad Sci U S A. 1968 Aug;60(4):1371-8. doi: 10.1073/pnas.60.4.1371.

The affinity-labeled residues in antibody active sites. II. Nearest-neighbor analyses.抗体活性位点中的亲和标记残基。II. 邻位分析。

Biochemistry. 1969 Nov;8(11):4523-34. doi: 10.1021/bi00839a045.

Localization within the heavy chain sequence of tyrosyl peptides from the combining sites in a rabbit anti-3-azopyridine antibody preparation.兔抗3-偶氮吡啶抗体制剂中结合位点酪氨酸肽重链序列内的定位

Biochem Biophys Res Commun. 1972 Sep 5;48(5):1208-14. doi: 10.1016/0006-291x(72)90839-x.

Characterization of the early primary antibody response to the 4-hydroxy-3-iodo-5-nitrophenylactate (NIP) and the 2,4-dimitrophenyl (DNP) determinants.对4-羟基-3-碘-5-硝基苯乙酸酯（NIP）和2,4-二硝基苯基（DNP）决定簇的早期初次抗体反应的特征分析。

Immunology. 1968 Dec;15(6):799-813.

Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide.结合硝基苯基配体的小鼠骨髓瘤蛋白的亲和标记。标记动力学及标记肽段的分离

Biochemistry. 1970 Mar 3;9(5):1267-78. doi: 10.1021/bi00807a031.

Affinity labeling by m-nitrobenzenediazonium fluoroborate of porcine anti-dinitrophenyl antibodies. Localization of labeled tyrosine in the -chains.用氟硼酸间硝基苯重氮盐对猪抗二硝基苯基抗体进行亲和标记。标记酪氨酸在重链中的定位。

Eur J Biochem. 1973 Feb 15;33(1):59-66. doi: 10.1111/j.1432-1033.1973.tb02654.x.

Neutralization of haptenated bacteriophage f2 by anti-hapten antibodies: direct evidence for a critical site.抗半抗原抗体对结合半抗原的噬菌体f2的中和作用：关键位点的直接证据。

J Immunol. 1972 Apr;108(4):927-36.

[Structure of peptides isolated from chymotrypsin hydrolysates of horse myoglobin].[从马肌红蛋白胰凝乳蛋白酶水解物中分离出的肽的结构]

Bull Soc Chim Biol (Paris). 1969 Jan 30;50(10):1651-69.

Valence and association constant of rat macroglobulin antibody.大鼠巨球蛋白抗体的效价与结合常数

J Immunol. 1971 Apr;106(4):932-7.

Degeneracy in the secondary immune response: stimulation of antibody formation by cross-reacting antigens.二次免疫反应中的简并性：交叉反应抗原对抗体形成的刺激

Isr J Med Sci. 1969 May-Jun;5(3):338-51.

引用本文的文献

Evolutionary pattern of specificity regions in light chains of immunoglobulins.免疫球蛋白轻链特异性区域的进化模式。

Biochem Genet. 1969 Apr;3(2):109-17. doi: 10.1007/BF00520347.

Site-directed cross-linking: a new approach to mapping antibody combining sites.定点交联：绘制抗体结合位点的一种新方法。

Proc Natl Acad Sci U S A. 1971 Jul;68(7):1421-4. doi: 10.1073/pnas.68.7.1421.

The covalent structure of an entire gammaG immunoglobulin molecule.完整的γG免疫球蛋白分子的共价结构。

Proc Natl Acad Sci U S A. 1969 May;63(1):78-85. doi: 10.1073/pnas.63.1.78.

[Molecular basis of antibody formation].[抗体形成的分子基础]

Naturwissenschaften. 1969 Apr;56(4):195-205. doi: 10.1007/BF01166814.

Six BALB-c IgA myeloma proteins that bind beta-(1-6)-D-galactan. Partial amino acid sequences and idiotypes.六种结合β-(1-6)-D-半乳聚糖的BALB-c IgA骨髓瘤蛋白。部分氨基酸序列和独特型。

J Exp Med. 1973 Nov 1;138(5):1095-105. doi: 10.1084/jem.138.5.1095.

Conformational significance of the intrachain disulfide linkages in immunoglobulins.免疫球蛋白中链内二硫键的构象意义

Proc Natl Acad Sci U S A. 1970 Nov;67(3):1085-92. doi: 10.1073/pnas.67.3.1085.

本文引用的文献

AFFINITY LABELING OF THE ACTIVE SITES OF ANTIBODIES TO THE 2,4-DINITROPHENYL HAPTEN.针对2,4 - 二硝基苯基半抗原的抗体活性位点的亲和标记

Biochemistry. 1963 Sep-Oct;2:979-88. doi: 10.1021/bi00905a014.

Affinity labeling-a general method for labeling the active sites of antibody and enzyme molecules.亲和标记——一种标记抗体和酶分子活性位点的通用方法。

Biochemistry. 1962 Nov;1:1031-9. doi: 10.1021/bi00912a013.

Reduction of gamma-globulins.γ球蛋白减少

Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80.

On structural and functional relations between antibodies and proteins of the gamma-system.关于抗体与γ-系统蛋白质之间的结构和功能关系

Proc Natl Acad Sci U S A. 1962 Jun 15;48(6):1035-42. doi: 10.1073/pnas.48.6.1035.

The preparation and some properties of purified antibody specific for the 2,4-dinitrophenyl group.针对2,4-二硝基苯基基团的纯化抗体的制备及其某些性质

J Exp Med. 1960 Dec 1;112(6):1195-210. doi: 10.1084/jem.112.6.1195.

Structure and function of haemoglobin. 3. A three-dimensional fourier synthesis of human deoxyhaemoglobin at 5.5 Angstrom resolution.血红蛋白的结构与功能。3. 5.5埃分辨率下人类脱氧血红蛋白的三维傅里叶合成。

J Mol Biol. 1967 Aug 28;28(1):117-56. doi: 10.1016/s0022-2836(67)80082-2.

Affinity labeling of the active sites of rabbit anti-2,4-dinitrophenyl antibodies with m-nitrobenzenediazonium fluoroborate.用间硝基苯重氮氟硼酸盐对兔抗2,4-二硝基苯基抗体的活性位点进行亲和标记。

Biochemistry. 1967 Mar;6(3):873-81. doi: 10.1021/bi00855a031.

Accelerated automatic chromatographic analysis of peptides on a spherical resin.球形树脂上肽的加速自动色谱分析

Anal Biochem. 1966 Jul;16(1):91-106. doi: 10.1016/0003-2697(66)90084-4.

Variations in amino-acid sequence near the disulphide bridges of Bence-Jones proteins.本-周蛋白二硫键附近氨基酸序列的变异

Nature. 1966 Jan 22;209(5021):370-3. doi: 10.1038/209370a0.

Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten and a structural relationship among antibody active sites of different specificities.对-偶氮苯基三甲基铵半抗原抗体的亲和标记及不同特异性抗体活性位点之间的结构关系

Biochem Biophys Res Commun. 1965 Jul 26;20(3):315-20. doi: 10.1016/0006-291x(65)90366-9.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验