芳香胺的N-甲酰化作为一种代谢途径。
N-Formylation of an aromatic amine as a metabolic pathway.
作者信息
Gothoskar S V, Benjamin T, Roller P P, Weisburger E K
出版信息
Xenobiotica. 1979 Sep;9(9):533-7. doi: 10.3109/00498257909042318.
PMID:524913
Abstract
- Feeding 2-aminoanthraquinone (2-AAQ) in the diet to Fischer rats led to nephrotoxicity in females, caused by deposits of crystalline material in the kidney tubules. 2. This material consisted of 2-AAQ, N-acetyl-2-AAQ and N-formyl-2-AAQ. N-Formyl-2-AAQ was also identified in the ether extract of urine of rats fed 2-AAQ. 3. This represents the first case of identification of the N-formyl derivative of a primary aromatic amine as a metabolite in vivo.
摘要
- 在饮食中给Fischer大鼠喂食2-氨基蒽醌（2-AAQ）会导致雌性大鼠出现肾毒性，这是由肾小管中结晶物质的沉积引起的。2. 这种物质由2-AAQ、N-乙酰基-2-AAQ和N-甲酰基-2-AAQ组成。在喂食2-AAQ的大鼠尿液的乙醚提取物中也鉴定出了N-甲酰基-2-AAQ。3. 这是首次鉴定出一种伯芳香胺的N-甲酰基衍生物作为体内代谢物的案例。
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