Gothoskar S V, Weisburger E K
Med Biol. 1980 Oct;58(5):281-4.
The role of gonadal hormones in the nephrotoxicity of the hepatocarcinogen 2-aminoanthraquinone (2-AAQ) was investigated. Intact and castrated four week old Fischer rats of both sexes and castrated female rats with subcutaneous implants of testosterone propionate pellets were fed 2% 2-AAQ in a Wayne meal diet. After 12 weeks of ad libitum feeding the animals were then given control diet. Based on survival, body, liver and kidney weights, and the histopathological evaluation of the kidneys, castrated female rats given testosterone propionate were afforded the greatest protective effect against the nephrotoxicity of 2-AAQ.
研究了性腺激素在肝癌致癌物2-氨基蒽醌（2-AAQ）肾毒性中的作用。给四周龄、未阉割和阉割的雌雄Fischer大鼠以及皮下植入丙酸睾酮丸剂的阉割雌性大鼠喂食含2% 2-AAQ的Wayne粉状饲料。自由采食12周后，再给动物喂食对照饲料。根据存活率、体重、肝脏和肾脏重量以及肾脏的组织病理学评估，皮下植入丙酸睾酮的阉割雌性大鼠对2-AAQ的肾毒性具有最大的保护作用。
