Wilson J D, Walker J D
J Clin Invest. 1969 Feb;48(2):371-9. doi: 10.1172/JCI105994.
The conversion of testosterone-1,2-(3)H to dihydrotestosterone by slices of human skin obtained from various anatomical sites in 112 normal subjects and three individuals with the syndrome of testicular feminization has been measured under standardized conditions. Very low rates of dihydrotestosterone formation were observed in sites obtained from the mons or from miscellaneous areas of the trunk and limbs of the control subjects. The mean rates of conversion were very high, however, in slices of skin obtained from several perineal sites (labia majora, scrotum, prepuce, and clitoris). Furthermore, as measured here, the rate of dihydrotestosterone formation by prepuce rises during the 3 months after birth and then falls progressively thereafter, reaching a level in the adult that is almost as low as that observed in the slices of nonperineal skin from all ages. In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects.
在标准化条件下，已对从112名正常受试者的不同解剖部位以及三名患有睾丸女性化综合征的个体获取的人体皮肤切片将睾酮 - 1,2 -（³H）转化为双氢睾酮的情况进行了测定。在对照组受试者的阴阜或躯干及四肢的其他部位获取的皮肤切片中，观察到双氢睾酮形成的速率非常低。然而，从几个会阴部位（大阴唇、阴囊、包皮和阴蒂）获取的皮肤切片中，转化的平均速率非常高。此外，如此处测量所示，包皮中双氢睾酮形成的速率在出生后的3个月内上升，然后逐渐下降，在成年人中达到的水平几乎与在各年龄段非会阴皮肤切片中观察到的水平一样低。在患有睾丸女性化综合征的患者中，从阴阜获取的皮肤切片中双氢睾酮的形成在正常范围内，而在大阴唇中观察到的速率低于正常受试者获得的平均值。
