Deslypere J P, Vermeulen A
J Clin Endocrinol Metab. 1985 Oct;61(4):648-53. doi: 10.1210/jcem-61-4-648.
In order to investigate whether androgen concentrations vary as a function of age in all tissues and organs and whether the sexual differences in plasma androgen levels are reflected in tissue concentrations, testosterone (T), 5 alpha-androstane-17 beta-ol, 3-one (DHT), 5 alpha-androstane-3 alpha,17 beta-diol (Adiol), and 4-androstene-3,17-dione (Adion) concentrations were measured postmortem in lung tissue and myocardium of men aged 16-87 yr. The results were compared to values obtained previously in other tissues. Similar measurements were made in various tissues (labia majora, clitoris, pubic skin, thigh skin, striated muscle) from women aged 16-87 yr. In cardiac tissue of men, T was quantitatively the most important androgen and concentrations of DHT and Adiol were low, reflecting low 5 alpha-reductase activity; in lung tissue, T and Adion were found in similar concentrations, with lower levels of 5 alpha-reduced metabolites. In both cardiac and lung tissue, androgen concentrations decreased significantly with age. In women, androgen concentrations were highest in specific androgen target tissues (labia majora, clitoris) and lowest in thigh skin and striated muscle. The ratios of the 5 alpha-saturated metabolites (DHT plus Adiol) to T or to T + Adion, respectively, parallel total androgen concentrations, whereas the Adiol to DHT ratio, a parameter of 3 alpha-reductase activity, was highest in striated muscle and thigh skin and lowest in androgen target tissues (labia majora and clitoris). In women tissue concentrations of all androgens decreased significantly with age in nearly all tissues studied. As expected tissue androgen concentrations were lower in women than in men, but in androgen target tissues such as the clitoris or labia majora, concentrations were little lower than in scrotal skin. We conclude that in both men and women androgen target tissues contain high androgen concentrations and high 5 alpha-reductase activity; moreover androgen concentrations in target tissues are similar in both sexes. In both sexes tissue androgen concentrations decreased with age in most tissues, but in target tissues the decrease was more pronounced in women than in men.
为了研究雄激素浓度是否会随年龄变化而在所有组织和器官中呈现不同，以及血浆雄激素水平的性别差异是否在组织浓度中有所体现，我们对16 - 87岁男性的肺组织和心肌进行了尸检，测量了睾酮（T）、5α - 雄甾烷 - 17β - 醇 - 3 - 酮（双氢睾酮，DHT）、5α - 雄甾烷 - 3α，17β - 二醇（Adiol）和4 - 雄烯二酮（Adion）的浓度。将结果与之前在其他组织中获得的值进行比较。对16 - 87岁女性的各种组织（大阴唇、阴蒂、耻骨皮肤、大腿皮肤、横纹肌）进行了类似测量。在男性心脏组织中，T在数量上是最重要的雄激素，DHT和Adiol的浓度较低，这反映了5α - 还原酶活性较低；在肺组织中，T和Adion的浓度相似，5α - 还原代谢物水平较低。在心脏和肺组织中，雄激素浓度均随年龄显著下降。在女性中，雄激素浓度在特定雄激素靶组织（大阴唇、阴蒂）中最高，在大腿皮肤和横纹肌中最低。5α - 饱和代谢物（DHT加Adiol）与T或与T + Adion的比值分别与总雄激素浓度平行，而Adiol与DHT的比值作为3α - 还原酶活性的参数，在横纹肌和大腿皮肤中最高，在雄激素靶组织（大阴唇和阴蒂）中最低。在几乎所有研究的女性组织中，所有雄激素的组织浓度均随年龄显著下降。正如预期的那样，女性的组织雄激素浓度低于男性，但在雄激素靶组织如阴蒂或大阴唇中，浓度仅略低于阴囊皮肤。我们得出结论，在男性和女性中，雄激素靶组织都含有高浓度的雄激素和高活性的5α - 还原酶；此外，靶组织中的雄激素浓度在两性中相似。在两性中，大多数组织的组织雄激素浓度随年龄下降，但在靶组织中，女性的下降比男性更明显。
