Winkler L, Schlag B, Franke S, Kessner C, Maess J, Pautzke M, Goetze E
Acta Biol Med Ger. 1979;38(4):611-7.
Pregnant Wistar rats were fed a fatfree diet from day 16--22 of pregnancy. On day 22, the fatty acid components of cholesterol esters, triglycerides, free fatty acids and phospholipids of maternal (brain, muscle, serum, white adipose tissue, liver) and fetal (brain, carcass, serum, liver) tissues, including the placenta, were examined gaschromatographically for the participation of linoleic and arachidonic acid. In all fetal and maternal organs the linoleic acid levels in the fatty acid patterns were strongly reduced. The alterations nearly always involved all the lipid fractions of a tissue and were mostly equal within a tissue. The strongest decreases of linoleic acid occurred in the placenta, and the weakest, in the lipids of maternal muscle and maternal adipose tissue. The linoleic acid alterations were principally similar in fetal and the corresponding maternal tissues, while being less pronounced in case of maternal muscle. The participation of arachidonic acid in the fatty acid pattern is completely retained in the lipids of fetal organs, and is even enhanced in those of the placenta.
妊娠第16至22天，给怀孕的Wistar大鼠喂食无脂饮食。在第22天，采用气相色谱法检测母体（脑、肌肉、血清、白色脂肪组织、肝脏）和胎儿（脑、躯体、血清、肝脏）组织（包括胎盘）中胆固醇酯、甘油三酯、游离脂肪酸和磷脂的脂肪酸成分，以研究亚油酸和花生四烯酸的参与情况。在所有胎儿和母体器官中，脂肪酸模式中亚油酸水平均显著降低。这些变化几乎总是涉及组织的所有脂质部分，且在一个组织内大多相同。亚油酸降低最明显的是胎盘，而母体肌肉和母体脂肪组织脂质中的降低最不明显。胎儿和相应母体组织中亚油酸的变化基本相似，不过母体肌肉中的变化不太明显。花生四烯酸在胎儿器官脂质中的脂肪酸模式中的参与情况完全保留，在胎盘脂质中甚至有所增加。
