油性载体对眼用毛果芸香碱浓度的影响。
Effect of oily vehicle on ocular pilocarpine concentration.
作者信息
Salminen L
出版信息
Acta Ophthalmol (Copenh). 1979 Aug;57(4):633-6. doi: 10.1111/j.1755-3768.1979.tb00510.x.
Abstract
The effect of 1.4% polyvinyl alcohol (PVA) vehicle and of castor oil vehicle on ocular pilocarpine concentration was studied by radioactive method in the rabbit eye. Statistically higher radioactivities were measured from the anterior surface structures of the eyes dropped with oily vehicle when compared to PVA vehicle at 120 min. It is concluded that the conjunctiva and the cornea serve as a drug reservoir for the longlasting drug effect observed in the literature after oily pilocarpine drops.
摘要
采用放射性方法在兔眼中研究了1.4%聚乙烯醇（PVA）载体和蓖麻油载体对眼用毛果芸香碱浓度的影响。与PVA载体相比，在120分钟时，用油性载体滴眼的眼睛前表面结构测得的放射性在统计学上更高。得出的结论是，结膜和角膜作为药物储库，可产生文献中所观察到的油性毛果芸香碱滴眼液后的持久药物作用。
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