Hardberger R, Hanna C, Boyd C M
Arch Ophthalmol. 1975 Jan;93(1):42-5. doi: 10.1001/archopht.1975.01010020046008.
Radioactive sodium pentechnetate Tc 99m was added to commonly used ophthalmic drug vehicles of saline, 1% methyicellulose, 1.4% polyvinyl alcohol, and a 6:4 mixture of white petrolatum-mineral oil ointment. These drug vehicles containing 99m Tc were placed on both rabbit and human eyes and the rate of disappearance of the radioactivity determined. The ocular retention of 99m Tc by the eye was much longer in the nonblinking eye regardless of the vehicle used. The rate of loss of 99m Tc from the eye was fastest with saline and slowest with the ointment, with methylcellulose and polyvinyl alcohol in between. The longest contact time of the drug vehicle with the eye is afforded by the use of the ointment vehicle and the covering of both eyes.
将放射性锝-99m喷替酸盐添加到常用的眼科药物载体中，这些载体包括生理盐水、1%甲基纤维素、1.4%聚乙烯醇以及白凡士林-矿物油软膏的6:4混合物。将这些含有锝-99m的药物载体分别置于兔眼和人眼上，并测定放射性物质的消失速率。无论使用何种载体，在不眨眼的眼睛中，锝-99m的眼部滞留时间要长得多。锝-99m从眼中流失的速率，以生理盐水最快，软膏最慢，甲基纤维素和聚乙烯醇介于两者之间。使用软膏载体并覆盖双眼可使药物载体与眼睛的接触时间最长。
