Burgér T, Schmelczer M, Ottó S
Folia Haematol Int Mag Klin Morphol Blutforsch. 1975;102(3):295-304.
In the introduction the authors describe the biological role of platelets, plasma protein, fibrinogen and erthrocytes as well as the methods of tagging, separating and measuring them. The advantage of platelet labelling with 75selenomethionine is that it allows production and life-span to be determined simultaneously, however, the in vivo measurements do not give information on the site of platelet sequestration. Protein anabolism as well as katabolism can be evaluated with it, and the simultaneous determination of platelet and fibrinogen turnover may be especially useful in pathological conditions. The determination of erythrocyte life-span with 75 selenomethionine does not give so much information as the 59Fe and 51Cr methods, but when used for the examination of cell kinetics in combination with the latter methods it may afford an insight into erythropoiesis. The biological and the effective half-life periods (Teff) of 75selenomethionine are probably shorter than indicated in the literature.
在引言部分，作者描述了血小板、血浆蛋白、纤维蛋白原和红细胞的生物学作用，以及标记、分离和测量它们的方法。用75硒蛋氨酸标记血小板的优点是可以同时测定其生成和寿命，然而，体内测量无法提供血小板滞留部位的信息。利用它可以评估蛋白质的合成代谢和分解代谢，同时测定血小板和纤维蛋白原的周转率在病理情况下可能特别有用。用75硒蛋氨酸测定红细胞寿命所提供的信息不如59铁和51铬方法多，但当与后两种方法结合用于细胞动力学检查时，它可能有助于深入了解红细胞生成。75硒蛋氨酸的生物学半衰期和有效半衰期（Teff）可能比文献中指出的要短。
