Dakkak R, Goussault Y, Dreux C
Ann Biol Clin (Paris). 1979;37(4):195-200.
The values of hydroxyprolinuria were determined in 314 cases of Paget's disease and 91 cases of osteoma. During Paget's disease, the values found were related to the degree of the bony disorder. A more detailed study of the hydroxyproline polypeptides was undertaken, comparatively in a few cases of these two diseases. In Paget's disease, there was shown a relative increase in the oligopeptide fraction, whereas the polypeptide fraction was increased in osteoma. By chromatographic and electrophoretic technics, it was shown that the acid oligopeptides (containing mainly the dipeptide (Glu-Hyp) are in percentage, reduced in Paget's disease and increased in osteoma, whereas the neutral oligopeptides (containing mainly Pro-Hyp) undergo the opposite variation in these two diseases.
测定了314例佩吉特氏病患者和91例骨瘤患者的羟脯氨酸尿值。在佩吉特氏病期间，所测得的值与骨病程度相关。对这两种疾病的少数病例进行了羟脯氨酸多肽的比较详细研究。在佩吉特氏病中，寡肽部分相对增加，而在骨瘤中多肽部分增加。通过色谱和电泳技术表明，酸性寡肽（主要含二肽（Glu-Hyp））的百分比在佩吉特氏病中降低而在骨瘤中增加，而中性寡肽（主要含Pro-Hyp）在这两种疾病中则呈现相反的变化。
