Fabier J L, Viau M, Constans J, Clerc A
Rev Rhum Mal Osteoartic. 1976 Apr;43(4):249-53.
The authors demonstrated in the urine of patients presenting Paget's bone disease a peptide rich in hydroxyproline. The level of this compound expressed as "norleucine equivalent" was determined by chromatographic analysis of the urinary amino acids. There was a very good correlation between the total hydroxyproline level and the quantity of this peptide in the urine. The authors isolated this peptide and determined that it contained 3 hydroxyprolines for every 2 glutamines. This peptide thus seems to indicate an anomaly in the chain of synthesis; a disorder of the collagen metabolism would produce in these patients large quantities of these molecules that are excreted via the kidney. At the present stage of the author's studies this urinary peptide appears to be "specific" to Pagets disease.
作者在患有佩吉特骨病的患者尿液中发现了一种富含羟脯氨酸的肽。该化合物的水平以“正亮氨酸当量”表示，通过对尿氨基酸进行色谱分析来测定。尿中总羟脯氨酸水平与该肽的量之间存在非常好的相关性。作者分离出了这种肽，并确定其每2个谷氨酰胺含有3个羟脯氨酸。因此，这种肽似乎表明合成链存在异常；胶原蛋白代谢紊乱会在这些患者体内产生大量通过肾脏排泄的此类分子。在作者研究的现阶段，这种尿肽似乎是佩吉特病“特有的”。
