Lassen E D, Buck W B
Am J Vet Res. 1979 Oct;40(10):1359-64.
Thirty pigs, weighing 17 to 24 kg, were exposed to lead or sodium acetate orally or intraperitoneally (IP) 6 days each week for 13 weeks. These pigs were extremely tolerant of lead. Only mild clinical signs of lead toxicosis were observed in orally lead-exposed pigs despite blood lead concentrations of up to 290 micrograms/dl. Four IP lead-exposed pigs died, but eight other IP lead-exposed pigs survived the exposure period despite blood lead concentrations up to 14,300 micrograms/dl. Lead exposure caused marked decreases in blood delta-aminolevulinic acid dehydratase activities of all pigs and moderate decreases of blood hemoglobin concentrations, hematocrit percentages, mean corpuscular volumes, mean corpuscular hemoglobin concentrations, and mean corpuscular hemoglobins in IP lead-exposed, but not in orally lead-exposed pigs. Basophilic stippling was observed in erythrocytes of lead-exposed pigs, but not in those of control pigs.
30头体重17至24千克的猪，每周6天经口或腹腔内（IP）给予铅或醋酸钠，持续13周。这些猪对铅具有极强的耐受性。尽管经口染铅猪的血铅浓度高达290微克/分升，但仅观察到轻度的铅中毒临床症状。4头经腹腔染铅的猪死亡，但另外8头经腹腔染铅的猪尽管血铅浓度高达14,300微克/分升，仍在暴露期存活下来。铅暴露导致所有猪的血δ-氨基乙酰丙酸脱水酶活性显著降低，经腹腔染铅的猪的血红蛋白浓度、血细胞比容百分比、平均红细胞体积、平均红细胞血红蛋白浓度和平均红细胞血红蛋白含量中度降低，但经口染铅的猪未出现这种情况。在染铅猪的红细胞中观察到嗜碱性点彩，但对照猪的红细胞中未观察到。
