Lassen E D, Hoffman L J, Kaeberle M L, Buck W B
Am J Vet Res. 1980 Apr;41(4):463-8.
The effect of oral subclinical lead exposure on the susceptibility of swine to Salmonella choleraesuis var kunzendorf was studied in two experiments. In experiment 1, 18 pigs were exposed to lead acetate and 18 pigs were exposed to sodium acetate for 1, 2, or 3 weeks and then challenge exposed intraperitoneally. In experiment 2, 8 pigs were exposed to lead chloride for 2 weeks, 8 pigs were exposed to lead chloride for 1 week, and 8 pigs were exposed to sodium chloride for 2 weeks. These pigs were then challenge exposed orally. Only one pig (sodium acetate-exposed) died during experiment 1, but clinical signs were more severe in sodium acetate-exposed than in lead acetate-exposed animals. In experiment 2, 93.6% of the lead-exposed pigs died, whereas control pigs had 50.0% mortality. In experiment 2, clinical signs were more severe in lead-exposed pigs, and bacteria were more widespread in the tissues of these animals. Significant reductions of beta- or gamma-globulin concentrations or of agglutinating antibody titers were not observed in lead-exposed pigs in either of the trials. Possible mechanisms of the increased susceptibility in lead-exposed pigs of experiment 2 are discussed.
在两项实验中研究了口服亚临床铅暴露对猪感染猪霍乱沙门氏菌孔岑多夫变种易感性的影响。在实验1中，18头猪暴露于醋酸铅，18头猪暴露于醋酸钠1、2或3周，然后进行腹腔内攻毒暴露。在实验2中，8头猪暴露于氯化铅2周，8头猪暴露于氯化铅1周，8头猪暴露于氯化钠2周。然后对这些猪进行口服攻毒暴露。在实验1期间只有1头猪（暴露于醋酸钠的猪）死亡，但暴露于醋酸钠的动物的临床症状比暴露于醋酸铅的动物更严重。在实验2中，93.6%的铅暴露猪死亡，而对照猪的死亡率为50.0%。在实验2中，铅暴露猪的临床症状更严重，并且细菌在这些动物的组织中分布更广泛。在两项试验中，铅暴露猪均未观察到β或γ球蛋白浓度或凝集抗体滴度的显著降低。讨论了实验2中铅暴露猪易感性增加的可能机制。
