Baber K A, Meyers K M, Clemmons R, Peters R
Am J Vet Res. 1979 Oct;40(10):1378-80.
Regional concentrations of tryptophan, serotonin (5HT), 5-hydroxyindoleacetic acid (5HIAA), norepinephrine, and dopamine were determined in the ovine brain. Tryptophan concentrations varied between 18.6 nmoles/g of tissue (hypothalamus, midbrain) and 26.9 nmoles/g (cerebellum). The 5HT concentrations varied 0.34 nmoles/g (cerebellum) and 3.75 nmoles/g (midbrain). The concentration of 5HIAA varied between 1.78 nmoles/g (cerebellum) and 5.02 nmoles/g (hypothalamus). Large concentrations of norepinephrine were found in the hypothalamus (4.37 nmoles/g) and midbrain (2.08 nmoles/g), while the frontal cortex, thalamaus, hippocampus, and cerebellum were all relatively low in norepinephrine (0.65 to 0.95 nmoles/g). The concentration of dopamine was between 0.32 nmoles/g (hippocampus) and 39.8 nmoles/g (caudate nucleus). Generally, the distribution of these compounds in the ovine brain is similar to their regional distribution in other mammalian species. It was observed, however, that the ratio of 5HT/5HIAA appears to be relatively lower in sheep than in other species, suggesting that interspecies differences in the metabolism of 5HT or elimination of 5HIAA (or both) may exist.
测定了绵羊大脑中色氨酸、5-羟色胺（5HT）、5-羟吲哚乙酸（5HIAA）、去甲肾上腺素和多巴胺的区域浓度。色氨酸浓度在每克组织18.6纳摩尔（下丘脑、中脑）至26.9纳摩尔（小脑）之间变化。5HT浓度在每克0.34纳摩尔（小脑）至3.75纳摩尔（中脑）之间变化。5HIAA浓度在每克1.78纳摩尔（小脑）至5.02纳摩尔（下丘脑）之间变化。在下丘脑（4.37纳摩尔/克）和中脑（2.08纳摩尔/克）中发现了大量的去甲肾上腺素，而额叶皮质、丘脑、海马体和小脑的去甲肾上腺素含量都相对较低（0.65至0.95纳摩尔/克）。多巴胺浓度在每克0.32纳摩尔（海马体）至39.8纳摩尔（尾状核）之间。一般来说，这些化合物在绵羊大脑中的分布与其在其他哺乳动物物种中的区域分布相似。然而，观察到绵羊的5HT/5HIAA比值似乎比其他物种相对较低，这表明5HT代谢或5HIAA消除（或两者）可能存在种间差异。
