体内同步化的小鼠淋巴瘤细胞对X射线的年龄反应
Age response to x-radiation of murine lymphoma cells synchronized in vivo.
作者信息
Mauro F, Madoc-Jones H
出版信息
Proc Natl Acad Sci U S A. 1969 Jul;63(3):686-91. doi: 10.1073/pnas.63.3.686.
Abstract
Cells of a transplantable murine lymphoma line were partially synchronized in vivo by administration of a single dose of 0.5 mg of hydroxyurea per lymphoma-bearing mouse. At various times after administration of hydroxyurea, the femurs of the lymphomatous mice were X-irradiated, and the number of lymphoma colony-forming units per femur were then assayed by the spleencolony technique. A well-defined age response to irradiation of the lymphoma cells in vivo, similar to that of HeLa cells in vitro, was observed.
摘要
通过给每只荷瘤小鼠单次注射0.5毫克羟基脲，可使可移植性小鼠淋巴瘤细胞系的细胞在体内实现部分同步化。在注射羟基脲后的不同时间，对淋巴瘤小鼠的股骨进行X射线照射，然后通过脾集落技术测定每根股骨中淋巴瘤集落形成单位的数量。观察到淋巴瘤细胞在体内对辐射呈现出明确的年龄反应，这与体外培养的HeLa细胞相似。
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