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中性氨基酸通过阳离子氨基酸转运系统进行的钠依赖性反应。

Na plus-facilitated reactions of neutral amino acids with a cationic amino acid transport system.

作者信息

Christensen H N, Handlogten M E, Thomas E L

出版信息

Proc Natl Acad Sci U S A. 1969 Jul;63(3):948-55. doi: 10.1073/pnas.63.3.948.

Abstract

The predominant basis for transport interactions between neutral and cationic amino acids in the Ehrlich ascites-tumor cell and the rabbit reticulocyte has been identified as a reaction of the neutral amino acid plus Na(+) with the cationic amino acid transport system. This reaction is revealed both by a Na(+)-dependent transport inhibition by the neutral amino acid, and by mutual flux accelerations whereby the neutral amino acid and Na(+) exchange for the cationic amino acid.

摘要

艾氏腹水癌细胞和兔网织红细胞中中性氨基酸与阳离子氨基酸之间转运相互作用的主要基础已被确定为中性氨基酸加Na(+)与阳离子氨基酸转运系统的反应。中性氨基酸对Na(+)依赖性转运的抑制以及中性氨基酸和Na(+)与阳离子氨基酸的相互通量加速都揭示了这一反应。

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