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Antimicrob Agents Chemother. 1979 May;15(5):658-61. doi: 10.1128/AAC.15.5.658.
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引用本文的文献

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本文引用的文献

1
A CONTROLLED DOUBLE-BLIND STUDY OF THE HEMATOLOGIC TOXICITY OF CHLORAMPHENICOL.氯霉素血液学毒性的对照双盲研究
N Engl J Med. 1965 Jun 3;272:1137-42. doi: 10.1056/NEJM196506032722201.
2
FATAL APLASTIC ANEMIA. AN EPIDEMIOLOGICAL STUDY OF ITS RELATIONSHIP TO THE DRUG CHLORAMPHENICOL.
J Chronic Dis. 1964 Oct;17:899-914. doi: 10.1016/0021-9681(64)90161-4.
3
Chloramphenicol in the newborn infant. A physiologic explanation of its toxicity when given in excessive doses.新生儿使用氯霉素。过量使用时其毒性的生理学解释。
N Engl J Med. 1960 Apr 21;262:787-94. doi: 10.1056/NEJM196004212621601.
4
Fatal circulatory collapse in premature infants receiving chloramphenicol.接受氯霉素治疗的早产儿发生致命性循环衰竭。
N Engl J Med. 1959 Dec 24;261:1318-21. doi: 10.1056/NEJM195912242612604.
5
An outbreak of neonatal deaths among term infants associated with administration of chloramphenicol.
J Pediatr. 1961 Jul;59:21-34. doi: 10.1016/s0022-3476(61)80205-9.
6
Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol.接受大量氯霉素治疗的婴儿发生致命性心血管虚脱。
AMA J Dis Child. 1959 Jun;97(6):761-7. doi: 10.1001/archpedi.1959.02070010763001.
7
Studies on excretion of antibiotics in human saliva. II. Chloramphenicol.人体唾液中抗生素排泄的研究。II. 氯霉素。
J Dent Res. 1953 Apr;32(2):287-93. doi: 10.1177/00220345530320021801.
8
Chloramphenicol-associated encephalopathy.
Clin Pharmacol Ther. 1970 Mar-Apr;11(2):194-9. doi: 10.1002/cpt1970112194.
9
Relationship between theophylline concentration in plasma and saliva of man.人体血浆与唾液中茶碱浓度的关系。
Clin Pharmacol Ther. 1974 May;15(5):454-60. doi: 10.1002/cpt1974155454.
10
The 'grey toddler'. Chloramphenicol toxicity.“灰色幼儿”。氯霉素毒性。
Arch Dis Child. 1974 Mar;49(3):235-7. doi: 10.1136/adc.49.3.235.

血清与唾液中氯霉素浓度的关系。

Relationship between serum and saliva chloramphenicol concentrations.

作者信息

Koup J R, Lau A H, Brodsky B, Slaughter R L

出版信息

Antimicrob Agents Chemother. 1979 May;15(5):658-61. doi: 10.1128/AAC.15.5.658.

DOI:10.1128/AAC.15.5.658
PMID:525981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352733/
Abstract

The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 +/- 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.

摘要

在20名住院患者接受氯霉素（CAP）治疗期间收集的27对样本中，评估了血清和唾液中氯霉素浓度之间的关系。发现存在显著（R = 0.80，P < 0.001）但多变的关系。还评估了氯霉素的血清蛋白结合情况（结合率为43.7 +/- 5.7%；N = 24）。氯霉素结合的差异显然并未占观察到的唾液/血清氯霉素浓度比值变异性的很大一部分。观察到的变异程度表明，不能依靠唾液氯霉素浓度来预测血清氯霉素浓度。