Koup J R, Lau A H, Brodsky B, Slaughter R L
Antimicrob Agents Chemother. 1979 May;15(5):658-61. doi: 10.1128/AAC.15.5.658.
The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 +/- 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.
在20名住院患者接受氯霉素(CAP)治疗期间收集的27对样本中,评估了血清和唾液中氯霉素浓度之间的关系。发现存在显著(R = 0.80,P < 0.001)但多变的关系。还评估了氯霉素的血清蛋白结合情况(结合率为43.7 +/- 5.7%;N = 24)。氯霉素结合的差异显然并未占观察到的唾液/血清氯霉素浓度比值变异性的很大一部分。观察到的变异程度表明,不能依靠唾液氯霉素浓度来预测血清氯霉素浓度。