Alluchon-Gérard M J
Arch Anat Microsc Morphol Exp. 1979;68(1):43-60.
From the 20 mm stage, in the cells of the dogfish embryo thyroid, some Golgi vesicles get the ability to trap iodine. At subsequent stages, electrondense intracytoplasmic cavities with microvilli are observed in the Golgi field; their membranes also trap iodine. These cavities increase in volume, draw toward the cellular periphery and export their contents in an intercellular space previously limited by tight junctions. The same events occur in several adjacent cells, which constitute the first follicular lumen. The last stage of follicular individualization is basement membrane formation. Arguments are given which support the hypothesis of the Golgi origin of intracytoplasmic cavities with microvilli. Iodine organification just as thyroid hormones synthesis and secretion occur at 25 mm stage, when cells are not grouped in follicle. It is concluded that cells containing intracytoplasmic cavities with microvilli are fully functional units.
从20毫米阶段开始，在角鲨胚胎甲状腺的细胞中，一些高尔基体囊泡获得了捕获碘的能力。在随后的阶段，在高尔基体区域观察到带有微绒毛的电子致密胞质内腔；它们的膜也能捕获碘。这些腔体积增大，向细胞周边移动，并将其内容物排到先前由紧密连接限制的细胞间隙中。几个相邻的细胞中会发生同样的事件，这些细胞构成了最初的滤泡腔。滤泡个体化的最后阶段是基底膜形成。文中给出了支持带有微绒毛的胞质内腔起源于高尔基体这一假说的论据。碘的有机化以及甲状腺激素的合成和分泌发生在25毫米阶段，此时细胞尚未聚集成滤泡。得出的结论是，含有带有微绒毛的胞质内腔的细胞是功能完备的单位。
