甲状腺滤泡形态发生机制：以胎儿腺体器官培养作为一种实验方法

Thyroid follicular morphogenesis mechanism: organ culture of the fetal gland as an experimental approach.

作者信息

Remy L, Verrier B, Michel-Bechet M, Mazzella E, Athouel-Haon A M

出版信息

J Ultrastruct Res. 1983 Mar;82(3):283-95. doi: 10.1016/s0022-5320(83)80015-x.

Abstract

The morphological and physiological changes induced by organ culture and thyroid-stimulating hormone (TSH) stimulation in the rat fetal thyroid gland were studied. Organ culture increased Golgi activity which was further enhanced by TSH, subsequently facilitating the formation of intracellular lumina. TSH also raised the intracellular cAMP level. The intracellular lumina observed during follicular morphogenesis are structurally comparable to typical intracellular cavities formed in adult thyroid cells, which are considered as being the result of increased Golgi activity. The intracellular lumen, therefore, is probably not a physiologically significant step in thyroid morphogenesis.

摘要

研究了器官培养和促甲状腺激素（TSH）刺激对大鼠胎儿甲状腺形态和生理变化的影响。器官培养增加了高尔基体活性，TSH进一步增强了这种活性，随后促进了细胞内腔的形成。TSH还提高了细胞内cAMP水平。在滤泡形态发生过程中观察到的细胞内腔在结构上与成年甲状腺细胞中形成的典型细胞内腔相似，后者被认为是高尔基体活性增加的结果。因此，细胞内腔可能不是甲状腺形态发生过程中具有生理意义的步骤。