Kasuya Y, Suzuki N
Arch Int Pharmacodyn Ther. 1979 Sep;241(1):24-31.
Sensitivity to norepinephrine (expressed as pD2) was different between the prostatic and the epididymal half of the rat vas deferens. The epididymal half was more sensitive than the prostatic half; difference in pD2 was 0.826 +/- 0.095 (mean +/- S.E., 13 experiments). Between the two halves, nearly the same difference in pD2, 0.745 +/- 0.125 (6 experiments), was observed in the responses to methoxamine, which is not incorporated into the adrenergic nerve terminals. In the two halves, 3 x 10(-6) M phentolamine produced a smiliar decrease in pD2 of norepinephrine: 1.485 +/- 0.056 and 1.282 +/- 0.080 in the prostatic and epididymal half, respectively (6 experiments). Only in the prostatic half, 10(-5) M propranolol produced a slight increase in pD2 of norepinephrine, 0.344 +/- 0.133 (6 experiments). Sensitivity to K+ was also different between the two halves. These results suggest that the difference in the sensitivity to norepinephrine between the prostatic and the epididymal half is due to postjunctional natures varying along the length of the rat vas deferens.
大鼠输精管前列腺段和附睾段对去甲肾上腺素的敏感性（以pD2表示）存在差异。附睾段比前列腺段更敏感；pD2的差异为0.826±0.095（平均值±标准误，13次实验）。在对不被肾上腺素能神经末梢摄取的甲氧明的反应中，两段之间观察到的pD2差异几乎相同，为0.745±0.125（6次实验）。在两段中，3×10⁻⁶M酚妥拉明使去甲肾上腺素的pD2产生类似程度的降低：前列腺段和附睾段分别为1.485±0.056和1.282±0.080（6次实验）。仅在前列腺段，10⁻⁵M普萘洛尔使去甲肾上腺素的pD2略有升高，为0.344±0.133（6次实验）。两段对K⁺的敏感性也不同。这些结果表明，大鼠输精管前列腺段和附睾段对去甲肾上腺素敏感性的差异是由于沿输精管长度方向的节后性质不同所致。
