Modak A T, Stavinoha W B, Hagino N
Arch Int Pharmacodyn Ther. 1979 Oct;241(2):344-50.
Subcutaneous administration of 0.05 mug estradiol benzoate to sexually immature female rats caused precocious ovulation and a decreased acetylcholine content in the hypothalamus and the amygdala. A higher dose of estradiol benzoate, 2 mug/rat, did not stimulate ovulation but did cause a further decrease in the acetylcholine content in the hypothalamus and the amygdala. The steady state levels of acetylcholine in the hippocampus and the striatum were unchanged with either dose of estradiol. These observations suggest a relationship between the occurrence of ovulation and the decrease in the steady state level of acetylcholine in the hypothalamus and amygdala in sexually immature rats after estradiol treatment.
对性未成熟的雌性大鼠皮下注射0.05微克苯甲酸雌二醇，可导致早熟排卵，并使下丘脑和杏仁核中的乙酰胆碱含量降低。更高剂量的苯甲酸雌二醇，即2微克/只大鼠，并未刺激排卵，但确实导致下丘脑和杏仁核中的乙酰胆碱含量进一步降低。两种剂量的雌二醇均未改变海马体和纹状体中乙酰胆碱的稳态水平。这些观察结果表明，在对性未成熟大鼠进行雌二醇治疗后，排卵的发生与下丘脑和杏仁核中乙酰胆碱稳态水平的降低之间存在关联。
