Musacchio J M, Julou L, Kety S S, Glowinski J
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1117-9. doi: 10.1073/pnas.63.4.1117.
A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.
在先前的一项研究中，观察到每天接受两次电惊厥休克、持续一周的大鼠大脑中，去甲肾上腺素的周转率持续增加，且该胺的浓度也升高。由于酪氨酸羟化酶似乎是去甲肾上腺素合成中的限速酶，因此通过研究类似的电惊厥休克方案对大脑中酪氨酸羟化酶的影响，对这一现象进行了进一步研究。在接受电休克治疗的动物中，发现全脑酶活性有小幅（15%）但显著的增加。在这些动物的脑干（24%）和皮层（20%）中，酪氨酸羟化酶活性显著增加。
