Needleman S B, Blair T T
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1227-33. doi: 10.1073/pnas.63.4.1227.
The homology of Pseudomonas cytochrome c-551 with eukaryotic cytochromes c is examined with a computer-based procedure devised to determine whether similarities exist between these proteins. One method is given by which the more recently evolved cytochromes c might have arisen from the Pseudomonas protein. This procedure involves only common genetic phenomena and accounts for most of the structural differences between the bacterial and mammalian cytochromes. A time-scale relationship between the c-cytochromes from several microorganisms, a mold, yeast, and the eukaryotic organisms is proposed.
利用一种基于计算机的程序来检测铜绿假单胞菌细胞色素c-551与真核细胞色素c的同源性，该程序旨在确定这些蛋白质之间是否存在相似性。文中给出了一种方法，据此可以推测较新进化的细胞色素c可能是由假单胞菌蛋白质演变而来。该程序仅涉及常见的遗传现象，并且解释了细菌和哺乳动物细胞色素之间的大部分结构差异。本文还提出了几种微生物、霉菌、酵母和真核生物的细胞色素c之间的时间尺度关系。
