[3例接受苯丁酸氮芥治疗的慢性幼年型关节炎患儿发生急性白血病]
[Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
作者信息
Buriot D, Prieur A M, Lebranchu Y, Messerschmitt J, Griscelli C
出版信息
Arch Fr Pediatr. 1979 Jun;36(6):592-8.
PMID:526114
Abstract
Three children out of a total of 40 who had been treated with chlorambucil for juvenile rheumatoid arthritis developed acute leukaemia. No malignancy was detected in 160 patients in those treated with steroids and/or other anti-inflammatory drugs. Chlorambucil may have induced the malignancies and its use should be avoided in rheumatoid arthritis.
摘要
在接受苯丁酸氮芥治疗幼年型类风湿关节炎的40名儿童中，有3名患了急性白血病。在接受类固醇和/或其他抗炎药物治疗的160名患者中未发现恶性肿瘤。苯丁酸氮芥可能诱发了恶性肿瘤，在类风湿关节炎治疗中应避免使用该药。
Zotero 插件