Gold F, Bourin M, Granry J C, Amine A, Breteau M, Laugier J
Arch Fr Pediatr. 1979 Jun;36(6):610-6.
Phenobarbital (20 mg/kg) was given intravenously to asphyxiated full term neonates who were less than 48 hours old. Further doses were given for 4 days (5 mgs/kg/d). Plasma levels were within the therapeutic range from 5 to 36 hours after the first injection but the maintenance dose always resulted in overdose by 5th day. The exact maintenance dose needs to be determined.
