Rossi E C
Artery. 1979 Mar;5(3):273-84.
Platelets play an important role in atherogenesis. This has given rise to the speculation that inhibitors of platelet function may prevent atherosclerotic changes. Two distinct therapeutic goals might be achieved by the use of inhibitors of platelet function in vascular disease - one, the prevention of thrombosis and, two, the prevention of atherosclerosis. The choice of inhibitor may well determine the goal achieved. Thus far, the data available indicate that inhibitors of platelet aggregation, such as aspirin, are the most effective in the prevention of thrombosis, while inhibitors of platelet adherence, such as dipyridamole, are likely to be the most effective in the prevention of atherosclerosis.
血小板在动脉粥样硬化形成过程中发挥着重要作用。这引发了一种推测，即血小板功能抑制剂可能预防动脉粥样硬化性改变。在血管疾病中使用血小板功能抑制剂可能实现两个不同的治疗目标——其一，预防血栓形成；其二，预防动脉粥样硬化。抑制剂的选择很可能决定所实现的目标。迄今为止，现有数据表明，血小板聚集抑制剂，如阿司匹林，在预防血栓形成方面最为有效，而血小板黏附抑制剂，如双嘧达莫，在预防动脉粥样硬化方面可能最为有效。
