Mustard J F, Moore S, Packham M A, Kinlough-Rathbone R L
Prog Biochem Pharmacol. 1977;13:312-25.
The interaction of platelets with the vessel wall can contribute to the early stages in the development of atherosclerosis through effects on smooth muscle cell proliferation, endothelial permeability, and possibly by causing vessel wall injury. Platelets are involved in the development of thrombi in response to vessel injury, and the repeated formation of platelet emboli and platelet-fibrin emboli from the mural thrombi may be one of the factors that cause clinical complications of atherosclerosis. Drugs which inhibit platelet function, particularly those that prolong shortened platelet survival (sulfinpyrazone and dipyridamole) may prove to be important in inhibiting the response of blood to vessel injury and thereby modifying the extent of atherosclerosis and its complications.
血小板与血管壁的相互作用可通过影响平滑肌细胞增殖、内皮通透性，并可能通过引起血管壁损伤，从而在动脉粥样硬化发展的早期阶段发挥作用。血小板参与血管损伤时血栓的形成，而壁血栓反复形成血小板栓子和血小板 - 纤维蛋白栓子可能是导致动脉粥样硬化临床并发症的因素之一。抑制血小板功能的药物，特别是那些能延长缩短的血小板存活时间的药物（磺吡酮和双嘧达莫），可能在抑制血液对血管损伤的反应、进而改变动脉粥样硬化及其并发症的程度方面具有重要作用。
