[Ultrastructural analysis of the effect of vagotomy on the state of the exocrine portion of the rat pancreas].

Dynamics of reactions in the main components of the exocrine part of the rat pancreas (capillary, nerve, pancreocyte) was subjected to ultrastructural analysis at bilateral subdiaphragmatic vagotomy within 24 hours--30 days. It was stated that certain ultrastructural shifts developed in all the components mentioned above; at first they are within the limits of physiological parameters (the first three days), and then destructive processes occur (up to destruction of a part of cells) reaching their maximum by the end of the first--beginning of the second week and having a focal character. Then compensatory-recovery rearrangements begin to predominate, and by the 30th day they result in a considerable but not yet complete normalization of the ultrastructural organization of the gland. Three stages (phases) can be mentioned in the development of the neurodistrophic process: the first--stress reaction of the organ and the whole organism to the operation; the second--predominance of destructive changes; the third--development of compensatory-adaptive processes. Possible mechanisms of the rearrangements occurring are discussed.