• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Pre-fork synthesis: a model for DNA replication.前叉合成：一种DNA复制模型。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1065-71. doi: 10.1073/pnas.64.3.1065.
2
Unchecked nick ligation can promote localized genome re-replication.未检查的尼克连接可促进局部基因组的重新复制。
Curr Biol. 2021 Jun 7;31(11):R710-R711. doi: 10.1016/j.cub.2021.03.043.
3
Escherichia coli PriA helicase: fork binding orients the helicase to unwind the lagging strand side of arrested replication forks.大肠杆菌PriA解旋酶：叉形结构结合使解旋酶定向，以解开停滞复制叉的滞后链一侧。
J Mol Biol. 2001 Oct 5;312(5):935-47. doi: 10.1006/jmbi.2001.4930.
4
Distribution of torsional stress between the un-replicated and replicated regions in partially replicated molecules.部分复制分子中未复制区和复制区之间的扭转应力分布。
J Biomol Struct Dyn. 2021 Apr;39(6):2266-2277. doi: 10.1080/07391102.2020.1751294. Epub 2020 Apr 10.
5
phiX174 cistron A protein is a multifunctional enzyme in DNA replication.噬菌体φX174的顺反子A蛋白是DNA复制中的一种多功能酶。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3198-202. doi: 10.1073/pnas.74.8.3198.
6
Rescue of stalled replication forks by RecG: simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation.RecG对停滞复制叉的拯救：在前导链和滞后链模板上同时易位支持了叉形反转和霍利迪连接形成的主动DNA解旋模型。
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8227-34. doi: 10.1073/pnas.111008698.
7
Replication fork reactivation downstream of a blocked nascent leading strand.受阻新生前导链下游的复制叉重新激活。
Nature. 2006 Feb 2;439(7076):557-62. doi: 10.1038/nature04329.
8
Methods to study the coupling between replicative helicase and leading-strand DNA polymerase at the replication fork.研究复制叉处复制性解旋酶与前导链DNA聚合酶之间偶联的方法。
Methods. 2016 Oct 1;108:65-78. doi: 10.1016/j.ymeth.2016.05.003. Epub 2016 May 9.
9
DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier.DNA 连接酶 4 在复制叉障碍处的叉崩溃时稳定核糖体 DNA 阵列。
DNA Repair (Amst). 2010 Aug 5;9(8):879-88. doi: 10.1016/j.dnarep.2010.05.003. Epub 2010 Jun 12.
10
Helicases at the replication fork.复制叉处的解旋酶。
Adv Exp Med Biol. 2013;767:97-121. doi: 10.1007/978-1-4614-5037-5_5.

引用本文的文献

1
Sensitivity of intracellular bacteriophage lambda to colicin CA42-E2.细胞内噬菌体λ对大肠杆菌素CA42-E2的敏感性
J Virol. 1971 Oct;8(4):355-62. doi: 10.1128/JVI.8.4.355-362.1971.
2
Monofunctional alkylating agent-induced inactivation, mutagenesis and DNA degradation in an Escherichia coli mutant deficient in DNA polymerase.单功能烷化剂在缺乏DNA聚合酶的大肠杆菌突变体中诱导的失活、诱变和DNA降解。
Mol Gen Genet. 1971;111(4):357-67. doi: 10.1007/BF00569788.
3
[Virus and DNA replication. Studies in bacteriophage X174].[病毒与DNA复制。噬菌体X174的研究]
Naturwissenschaften. 1971 Jun;58(6):284-93. doi: 10.1007/BF00624733.
4
Role of gene 52 in bacteriophage T4 DNA synthesis.基因52在噬菌体T4 DNA合成中的作用。
J Virol. 1973 Jun;11(6):862-71. doi: 10.1128/JVI.11.6.862-871.1973.
5
Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 .大肠杆菌中质粒复制的温度敏感突变体：质粒ColE1复制中对脱氧核糖核酸聚合酶I的需求
J Bacteriol. 1973 Jun;114(3):1116-24. doi: 10.1128/jb.114.3.1116-1124.1973.
6
Ribonucleotides covalently linked to deoxyribonucleic acid in T4 bacteriophage.核糖核苷酸与T4噬菌体中的脱氧核糖核酸共价连接。
J Virol. 1972 Nov;10(5):902-8. doi: 10.1128/JVI.10.5.902-908.1972.
7
Filamentous bacterial viruses. V. Asymmetric replication of fd duplex deoxyribonucleic acid.丝状细菌病毒。V. fd双链脱氧核糖核酸的不对称复制。
J Virol. 1972 Sep;10(3):371-83. doi: 10.1128/JVI.10.3.371-383.1972.
8
Regions of single-stranded DNA in the growing points of replicating bacteriophage T7 chromosomes.正在复制的噬菌体T7染色体生长点中的单链DNA区域。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2682-6. doi: 10.1073/pnas.69.9.2682.
9
The occurrence of two types of synthesis of deoxyribonucleic acid during normal growth in Bacillus subtilis.枯草芽孢杆菌正常生长过程中脱氧核糖核酸两种合成类型的出现。
Biochem J. 1973 Oct;135(2):315-25. doi: 10.1042/bj1350315.

本文引用的文献

1
Biologic synthesis of deoxyribonucleic acid.脱氧核糖核酸的生物合成
Science. 1960 May 20;131(3412):1503-8. doi: 10.1126/science.131.3412.1503.
2
SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.DNA大小与形状的沉降研究
J Mol Biol. 1965 Feb;11:373-90. doi: 10.1016/s0022-2836(65)80064-x.
3
A COMPARISON OF THE INITIAL ACTIONS OF SPLEEN DEOXYRIBONUCLEASE AND PANCREATIC DEOXYRIBONUCLEASE.脾脏脱氧核糖核酸酶与胰腺脱氧核糖核酸酶初始作用的比较
J Biol Chem. 1965 Mar;240:1274-80.
4
ISOLATION OF THE GROWING POINT IN THE BACTERIAL CHROMOSOME.细菌染色体生长点的分离
Proc Natl Acad Sci U S A. 1964 Jul;52(1):125-32. doi: 10.1073/pnas.52.1.125.
5
A THEORY OF CROSSING-OVER BY MEANS OF HYBRID DEOXYRIBONUCLEIC ACID.一种借助杂交脱氧核糖核酸实现交换的理论。
Nature. 1963 Sep 14;199:1034-40. doi: 10.1038/1991034a0.
6
The bacterial chromosome and its manner of replication as seen by autoradiography.通过放射自显影观察到的细菌染色体及其复制方式。
J Mol Biol. 1963 Mar;6:208-13. doi: 10.1016/s0022-2836(63)80070-4.
7
Sequential replication of the Bacillus subtilis chromosome. II. Isotopic transfer experiments.枯草芽孢杆菌染色体的顺序复制。II. 同位素转移实验。
Proc Natl Acad Sci U S A. 1963 Jun;49(6):806-13. doi: 10.1073/pnas.49.6.806.
8
Changes in the physical state of DNA during the replication cycle.DNA在复制周期中的物理状态变化。
Proc Natl Acad Sci U S A. 1963 Mar 15;49(3):386-92. doi: 10.1073/pnas.49.3.386.
9
The molecular synchrony and sequential replication of DNA in Escherichia coli.大肠杆菌中DNA的分子同步性和序列复制
Proc Natl Acad Sci U S A. 1963 Apr;49(4):551-9. doi: 10.1073/pnas.49.4.551.
10
Polynucleotide cellulose as a substrate for a polynucleotide ligase induced by phage T4.多核苷酸纤维素作为噬菌体T4诱导的多核苷酸连接酶的底物。
Biochem Biophys Res Commun. 1967 Aug 23;28(4):578-86. doi: 10.1016/0006-291x(67)90353-1.

前叉合成：一种DNA复制模型。

Pre-fork synthesis: a model for DNA replication.

作者信息

Haskell E H, Daverin C I

出版信息

Proc Natl Acad Sci U S A. 1969 Nov;64(3):1065-71. doi: 10.1073/pnas.64.3.1065.

DOI:10.1073/pnas.64.3.1065
PMID:5264136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223344/
Abstract

A model of DNA replication is presented in which DNA synthesis is continuously initiated from parental strand nicks and occurs, with conservation of helix winding number, ahead of the so-called replicating fork. The fork in this model is the locus of unwinding of already replicated, but presumably unstable, DNA. The model, involving Okazaki's notion of multiple initiation, is based upon the properties of Kornberg's DNA polymerase and accounts for the presence of single-stranded nascent DNA fragments in cell lysates. In addition to acting as sites of initiation, the parental strand nicks are implicated as sites of free rotation allowing unwinding of the replicated DNA.

摘要

本文提出了一种DNA复制模型，其中DNA合成从亲代链切口处持续起始，并在所谓的复制叉之前进行，同时保持螺旋缠绕数不变。该模型中的复制叉是已复制但可能不稳定的DNA解旋的位点。这个涉及冈崎多重起始概念的模型基于科恩伯格DNA聚合酶的特性，并解释了细胞裂解物中存在单链新生DNA片段的现象。亲代链切口除了作为起始位点外，还被认为是自由旋转的位点，允许复制的DNA解旋。