λ阻遏蛋白对RNA聚合酶与DNA结合的影响。
Effect of the lambda repressor on the binding of RNA polymerase to DNA.
作者信息
Hayward W S, Green M H
出版信息
Proc Natl Acad Sci U S A. 1969 Nov;64(3):962-9. doi: 10.1073/pnas.64.3.962.
Abstract
Experiments were designed with the aim of understanding the mechanism whereby the lambda repressor inhibits messenger RNA synthesis. Complexes containing lambda DNA and RNA polymerase were isolated from repressed and derepressed lysogens and analyzed for the relative amounts of RNA polymerase per phage genome. The data indicate that the repressor inhibits the binding of RNA polymerase to promoter sites known to be under direct control of the repressor.
摘要
实验旨在了解λ阻遏物抑制信使核糖核酸合成的机制。从受抑制和去抑制的溶源菌中分离出含有λ DNA和RNA聚合酶的复合物，并分析每个噬菌体基因组中RNA聚合酶的相对含量。数据表明，阻遏物抑制RNA聚合酶与已知受阻遏物直接控制的启动子位点的结合。
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