Lee J C, Downing S E
Biol Neonate. 1979;36(5-6):255-63. doi: 10.1159/000241237.
Respiratory activity (RA) was assessed in a piglet model by giving chloralose (Ch), 6 mg/kg i.v. every 2 min, until the appearance of apnea. The total cumulative dose of Ch (mg/kg) which produced permanent apnea (lethal dose, LD) was determined. The slope of the dose-respiratory frequency curve (R = ae-lambda Ch) was also computed. The LD of Ch increased progressively with age, while respiratory frequency (lambda) decreased. However, in piglets with severe spontaneous anemia (hematocrit less than 10%), the LD of Ch was less than half that expected for the age groups, and the rate of reduction of gamma was much greater. The enhanced sensitivity to inhibition of RA may relate in part to anemia with reduced O2-carrying capacity to the CNS, and in part to growth retardation with delayed respiratory center maturation.
在仔猪模型中，通过静脉注射水合氯醛（Ch）来评估呼吸活动（RA），每2分钟注射6mg/kg，直至出现呼吸暂停。确定产生永久性呼吸暂停（致死剂量，LD）的Ch的总累积剂量（mg/kg）。还计算了剂量-呼吸频率曲线（R = ae-lambda Ch）的斜率。Ch的LD随年龄逐渐增加，而呼吸频率（lambda）则降低。然而，在患有严重自发性贫血（血细胞比容低于10%）的仔猪中，Ch的LD不到该年龄组预期值的一半，且gamma的降低速率要大得多。对RA抑制的敏感性增强可能部分与中枢神经系统携氧能力降低的贫血有关，部分与呼吸中枢成熟延迟的生长迟缓有关。
