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黄曲霉毒素B1诱导的肝癌发生：致癌物的细胞定位与大鼠肝脏早期组织学变化之间的关系

Hepatocarcinogenesis by aflatoxin B1: relationships between the cellular localization of the carcinogen and early histological changes in the rat liver.

作者信息

Stora C, Aussel C, Mayzaud O, Masseyeff R

出版信息

Biomedicine. 1979 Oct;31(6):173-6.

PMID:526538
Abstract

Aflatoxin B1 (and/or its fluorescent metabolites) was identified by fluorescence microscopy in the liver of rats fed with this carcinogen. The timing of appearance of the carcinogen in the cytoplasm and nuclei of hepatocytes is analysed in relation to the various early histological changes observed in the liver.

摘要

通过荧光显微镜在喂食这种致癌物的大鼠肝脏中鉴定出黄曲霉毒素B1（和/或其荧光代谢产物）。结合在肝脏中观察到的各种早期组织学变化，分析了致癌物在肝细胞细胞质和细胞核中出现的时间。

相似文献

1
Hepatocarcinogenesis by aflatoxin B1: relationships between the cellular localization of the carcinogen and early histological changes in the rat liver.黄曲霉毒素B1诱导的肝癌发生：致癌物的细胞定位与大鼠肝脏早期组织学变化之间的关系
Biomedicine. 1979 Oct;31(6):173-6.
2
Intracellular localization of aflatoxin B1 in rat and human livers.
J Environ Pathol Toxicol Oncol. 1990 May-Jun;10(3):129-31.
3
Carcinogen-protein complexes in liver during hepatocarcinogenesis by aflatoxin B1(1).
Cancer Res. 1977 Dec;37(12):4304-12.
4
Ovarian function during aflatoxin B1-induced hepatocarcinogenesis in the rat.
Res Commun Chem Pathol Pharmacol. 1986 Aug;53(2):183-94.
5
Inhibition of mitochondrial protein synthesis during early stages of aflatoxin B1-induced hepatocarcinogenesis.黄曲霉毒素B1诱导肝癌发生早期线粒体蛋白质合成的抑制作用。
Cancer Res. 1982 May;42(5):1876-80.
6
Quantitation of aflatoxin B1-modified DNA using monoclonal antibodies.使用单克隆抗体对黄曲霉毒素B1修饰的DNA进行定量分析。
Cancer Res. 1982 Aug;42(8):3120-4.
7
Comparative ultrastructural effects of aflatoxin B1 on mouse, rat, and human hepatocytes in primary culture.黄曲霉毒素B1对原代培养的小鼠、大鼠和人肝细胞超微结构的比较影响。
Cancer Res. 1986 Mar;46(3):1290-6.
8
In vitro metabolism of aflatoxin B2 by animal and human liver.
Cancer Res. 1978 Apr;38(4):999-1002.
9
The effects of prolonged feeding with aflatoxin B1 on adult rat liver.
Cancer Res. 1976 Jul;36(7 PT 1):2399-407.
10
Some effects of acute and chronic dosing with aflatoxin B1 on rat liver nuclei.
Cancer Res. 1976 May;36(5):1771-8.

引用本文的文献

1
Histofluorescence technique for the intracellular localization of chemical carcinogens.用于化学致癌物细胞内定位的组织荧光技术。
Histochem J. 1980 Nov;12(6):631-40. doi: 10.1007/BF01012018.
2
Sequential biochemical and histological changes in rats treated with aflatoxin B1.用黄曲霉毒素B1处理的大鼠的序贯生化和组织学变化
Br J Cancer. 1980 Aug;42(2):319-25. doi: 10.1038/bjc.1980.233.
3
Evidence of aflatoxin B1 in two cases of lung cancer in man.黄曲霉毒素B1在两例人类肺癌病例中的证据。
J Cancer Res Clin Oncol. 1981;100(2):221-4. doi: 10.1007/BF00403368.