石胆酸对培养的大鼠肝细胞的增殖作用。
Proliferative effect of lithocholic acid on rat liver cell in culture.
作者信息
Jeannin J F, Chessebeuf M, Martin M S, Lagneau A, Martin F
出版信息
Biomedicine. 1979 Nov;31(7):207-9.
PMID:526544
Abstract
In contrast to cholic acid, deoxycholic acid and chenodeoxycholic acid, lithocholic acid (LCA) enhances the growth of rat liver cells in culture. Enhanced proliferation of LCA-treated rat liver cells persists even 12 days after LCA was removed. These findings could suggest a mutagenic effect of LCA, or a metabolite, on rat liver cells.
摘要
与胆酸、脱氧胆酸和鹅脱氧胆酸不同，石胆酸（LCA）可促进培养的大鼠肝细胞生长。即使在去除LCA后12天，经LCA处理的大鼠肝细胞的增殖增强仍持续存在。这些发现可能提示LCA或其一种代谢产物对大鼠肝细胞具有诱变作用。
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