Gregus Z, Varga F, Fischer E
Acta Physiol Acad Sci Hung. 1982;59(1):89-97.
The effects of lithocholic acid (LCA), chenodeoxycholic acid (CDCA), deoxycholic acid (DOCA), cholic acid (CA) and dehydrocholic acid (DHCA) on the biliary excretion of amaranth (AM) in rats and on the respiration of isolated liver mitochondria were investigated. Bile acids diminished the biliary excretion of AM, and in vitro they enhanced the state 4 mitochondrial respiration and inhibited DNP- and ADP-stimulated oxygen consumption. The ID50 values (mumol/kg i.v.) and I50 concentrations (X 10(-5) M) of the bile acids for inhibiting AM excretion and ADP-stimulated mitochondrial respiration, respectively, were as follows: for LCA 16 and 3.3, for CDCA 160 and 24, for DOCA 230 and 31, for CA 680 and 105, and for DHCA 700 and 260. LCA, CDCA and DOCA inhibited the biliary excretion of AM uncompetitively. It is concluded that the toxic effect of LCA, CDCA and DOCA on mitochondria might play a role in their inhibitory action on the biliary transport of AM.
研究了石胆酸（LCA）、鹅去氧胆酸（CDCA）、脱氧胆酸（DOCA）、胆酸（CA）和脱氢胆酸（DHCA）对大鼠苋菜红（AM）胆汁排泄及离体肝线粒体呼吸的影响。胆汁酸减少了AM的胆汁排泄，并且在体外它们增强了线粒体状态4呼吸并抑制了二硝基苯酚（DNP）和二磷酸腺苷（ADP）刺激的氧消耗。胆汁酸抑制AM排泄和ADP刺激的线粒体呼吸的半数抑制剂量（ID50值，μmol/kg静脉注射）和半数抑制浓度（I50浓度，X 10(-5) M）分别如下：LCA为16和3.3，CDCA为160和24，DOCA为230和31，CA为680和105，DHCA为700和260。LCA、CDCA和DOCA非竞争性抑制AM的胆汁排泄。得出结论，LCA、CDCA和DOCA对线粒体的毒性作用可能在它们对AM胆汁转运的抑制作用中起作用。
