Gillespie E, Lichtenstein L M
J Immunol. 1975 Dec;115(6):1572-6.
The antigen-induced IgE-mediated release of histamine from human basophils has previously been shown to require calcium, to be inhibited by agents which raise cyclic AMP levels and by high antigen levels, and to be unaffected by cyclic GMP. The interrelationship between these phenomena has been studied. The major findings are: 1) in the region of antigen-excess inhibition dibutyryl cyclic AMP potentiates release; 2) antigen-excess inhibition is seen at lower antigen concentrations when the calcium concentration is reduced from 0.6 to 0.1 mM; and 3) cyclic GMP modestly potentiates release when the calcium concentration is 0.1 mM.
先前已表明，抗原诱导的人嗜碱性粒细胞中组胺的IgE介导释放需要钙，可被提高环磷酸腺苷（cAMP）水平的试剂以及高抗原水平所抑制，且不受环磷酸鸟苷（cGMP）影响。已对这些现象之间的相互关系进行了研究。主要发现如下：1）在抗原过量抑制区域，二丁酰环磷酸腺苷增强释放；2）当钙浓度从0.6 mM降至0.1 mM时，在较低抗原浓度下可观察到抗原过量抑制；3）当钙浓度为0.1 mM时，环磷酸鸟苷适度增强释放。
