人白细胞组胺释放：细胞松弛素B敏感屏障的调节作用
Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.
作者信息
Colten H R, Gabbay K H
出版信息
J Clin Invest. 1972 Jul;51(7):1927-31. doi: 10.1172/JCI106998.
Abstract
Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).
摘要
细胞松弛素B是几种真菌的代谢产物，可将人类白细胞对抗原E或抗IgE介导的组胺释放的敏感性和反应性提高多达10倍。细胞松弛素B的作用是其作用于组胺释放的第二个阶段（与抗原无关的阶段）的结果。这些数据表明，正常情况下，抗原触发的组胺释放受细胞松弛素敏感屏障（CSB）的调节。组胺释放的这种CSB调节可以与环磷酸腺苷（AMP）的调节作用区分开来。
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