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人白细胞组胺释放：细胞松弛素B敏感屏障的调节作用

Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.

作者信息

Colten H R, Gabbay K H

出版信息

J Clin Invest. 1972 Jul;51(7):1927-31. doi: 10.1172/JCI106998.

DOI:10.1172/JCI106998
PMID:4113392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC292344/
Abstract

Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).

摘要

细胞松弛素B是几种真菌的代谢产物，可将人类白细胞对抗原E或抗IgE介导的组胺释放的敏感性和反应性提高多达10倍。细胞松弛素B的作用是其作用于组胺释放的第二个阶段（与抗原无关的阶段）的结果。这些数据表明，正常情况下，抗原触发的组胺释放受细胞松弛素敏感屏障（CSB）的调节。组胺释放的这种CSB调节可以与环磷酸腺苷（AMP）的调节作用区分开来。

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引用本文的文献

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本文引用的文献

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A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。
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Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes.细胞松弛素B：对黑素细胞内微丝及黑素颗粒移动的影响
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Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.大鼠IgE的免疫化学和生物学特性。3. 影响环磷酸腺苷水平的试剂对IgE介导的过敏反应慢反应物质释放的调节作用。
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Cytochalasin B inhibits thyroid secretion.细胞松弛素B抑制甲状腺分泌。
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