O'Donohue T L, Massari V J, Tizabi Y, Jacobowitz D M
Brain Res Bull. 1979 Nov-Dec;4(6):829-32. doi: 10.1016/0361-9230(79)90019-4.
The distribution of alpha-melantropin-like material (alpha-MSH) was demonstrated in rat brain using a microdissection technique combined with radioimmunoassay. Highest concentrations of alpha-MSH were noted in the hypothalamus and preoptic area. Particularly high concentrations were observed in the arcuate nucleus, median eminence, suprachiasmatic nucleus, periventricular nucleus and the medial preoptic nucleus. The thalamic paraventricular nucleus also contained high alpha-MSH concentrations. Moderate to low concentrations were noted in other thalamic, septal, amygdaloid and midbrain nuclei. Low concentrations were observed in cortical and striatal regions.
采用显微解剖技术结合放射免疫分析法，在大鼠脑中证实了α-促黑素样物质（α-MSH）的分布。在下丘脑和视前区观察到α-MSH的浓度最高。在弓状核、正中隆起、视交叉上核、室周核和内侧视前核中观察到特别高的浓度。丘脑室旁核也含有高浓度的α-MSH。在其他丘脑、隔区、杏仁核和中脑核中观察到中度至低度浓度。在皮质和纹状体区域观察到低浓度。
