Friedman M J, Ewy G A, Jones S E, Cruze D, Moon T E
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1809-16.
To study the natural history of the alterations in cardiac function produced by Adriamycin therapy, serial M-mode echocardiograms, electrocardiograms, and systolic time intervals were obtained in 15 patients prior to Adriamycin therapy and at 3-month intervals during and 1 year after cessation of therapy. The echocardiographic E-point septal separation increased from a median 0 dose value of 0.40 cm to 0.70 cm (P less than 0.003) at the time of the maximum dose of Adriamycin. The electrocardiographic frontal plane voltage decreased 13% (P less than 0.008) and the pre-ejection period/left ventricular ejection time ratio increased from a median value of 0.37 to 0.40 (P less than 0.01) during this same period. During the first year after Adriamycin was discontinued, no significant change was noted in any of these values. Thus, as a group, the slight deterioration of ventricular function that occurred during Adriamycin therapy remained unimproved during the 1-year followup period.
为研究阿霉素治疗所导致的心脏功能改变的自然病程，在15例患者接受阿霉素治疗前、治疗期间每3个月以及停药后1年期间，每隔3个月进行系列M型超声心动图、心电图及收缩期时间间期检查。在阿霉素最大剂量时，超声心动图的E点室间隔距离从中位数0剂量时的0.40厘米增加到0.70厘米（P<0.003）。同期，心电图额面电压下降13%（P<0.008），射血前期/左心室射血时间比值从中位数0.37增加到0.40（P<0.01）。在停用阿霉素后的第一年，这些值均未出现显著变化。因此，总体而言，在阿霉素治疗期间出现的心室功能轻度恶化在1年随访期内仍未改善。
