Bertazzoli C, Bellini O, Magrini U, Tosana M G
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1877-83.
Adriamycin cardiotoxicity was morphologically evaluated in mice treated iv ten times at three dose levels which were equal to fixed fractions of the LD50. Good correlation between the degenerative heart lesions, scored according to a nonparametric scoring system, and the doses was found and allowed calculation of a median cumulative cardiotoxic dose of 36.4 mg/kg of body weight (121.5 mg/m2). The method is suitable for quantitative screening of the potential cardiotoxicity of new anthracycline analogs under standardized conditions.
对静脉注射给药10次、剂量水平为LD50固定分数的三个剂量组的小鼠进行阿霉素心脏毒性的形态学评估。根据非参数评分系统对退行性心脏病变进行评分，发现病变与剂量之间具有良好的相关性，据此计算出中位累积心脏毒性剂量为36.4mg/kg体重（121.5mg/m²）。该方法适用于在标准化条件下对新的蒽环类类似物潜在心脏毒性进行定量筛选。
