Gol'dberg L E, Shepelevtseva N G, Belova I P, Vertogradova T P
Antibiotiki. 1976 Dec;21(12):1106-13.
The cardiotoxic effect of karminomycin and adriamycin administered intravenously for 5 times in equitoxic doses constituting equal portions of LD50 of the respective antibiotic on its single intravenous administration was studied on albino mice. Histological examination of the heart showed that almost identical damages of the myocardium occured after administration of karminomycin and adriamycin in doses of 0.45 of LD50 (1.5 mg/kg) and 0.3 of LD50 (6.3 mg/kg) respectively. The character of the damages due to the antibiotics was close, the most significant changes were observed when the animals were sacrificed 1 month after the last administration of the drug. The histological method is of value in estimation of the cardiotoxic effect of the drugs, using mice as the model suitable for the investigation. Adriamycin had more pronounced cumulative properties as compared to karminomycin: suppression of the weight gain in the mice and their death rate were higher with the use of adriamycin.
在白化小鼠身上研究了卡米诺霉素和阿霉素静脉注射5次的心脏毒性作用，所用剂量为各自抗生素单次静脉注射LD50的等份且毒性相等。心脏组织学检查表明，分别给予0.45 LD50（1.5毫克/千克）的卡米诺霉素和0.3 LD50（6.3毫克/千克）的阿霉素后，心肌出现了几乎相同的损伤。抗生素所致损伤的特征相近，在最后一次给药后1个月处死动物时观察到最显著的变化。组织学方法在评估药物的心脏毒性作用方面具有价值，以小鼠作为适合该研究的模型。与卡米诺霉素相比，阿霉素具有更明显的累积特性：使用阿霉素时小鼠体重增加的抑制和死亡率更高。
