Kovach J S, Moertel C G, Schutt A J, Eagan R T
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1965-9.
Hycanthone, an antischistosomal drug possessing activity against experimental murine tumors, was administered by 20-minute infusion daily x 5 days to 12 patients with advanced cancer to determine dose-limiting toxicity and to look for therapeutic effect. No objective responses were seen. The dose-limiting toxic effect was acute hepatitis occurring in two of four patients treated at 100 mg/m2/day x 5. Moderate nausea and vomiting occurring on treatment days was the only other toxic effect. Hycanthone was not myelosuppressive. Assay of plasma concentrations of hycanthone revealed a plasma half-life of 3-5 hours and no accumulation of drug over the 5 days of treatment.
海恩酮是一种抗血吸虫药物，对实验性鼠肿瘤有活性。对12例晚期癌症患者每天输注20分钟，连续5天给予海恩酮，以确定剂量限制性毒性并寻找治疗效果。未观察到客观反应。剂量限制性毒性作用是急性肝炎，在4例接受100mg/m²/天×5天治疗的患者中有2例出现。治疗期间出现的中度恶心和呕吐是唯一的其他毒性作用。海恩酮无骨髓抑制作用。海恩酮血浆浓度测定显示血浆半衰期为3至5小时，且在治疗的5天内药物无蓄积。
