Marsh W L, Uretsky S C, Douglas S D
J Pediatr. 1975 Dec;87(6 Pt 2):1117-20. doi: 10.1016/s0022-3476(75)80124-7.
KX, an antigen related to the Kell blood group system, is present in trace amounts on normal red cells and is strongly active on the neutrophils of all of 50 persons thus far tested. Normal circulating monocytes are now shown to also bear KX determinants. Absence of neutrophil KX has been associated with all of three previously tested patients with chronic granulomatous disease. In this study two male siblings with CGD also have been shown to have KX negative leukocytes, and white blood cells from their heterozygous mother were found to have a reduced competency to absorb anti-KX. Five CGD boys are known to lack KX; the probability of this occurring by chance is greater 10(-6).
KX是一种与凯尔血型系统相关的抗原，在正常红细胞上含量微量，而在迄今检测的所有50人的中性粒细胞上活性很强。现已证明正常循环单核细胞也带有KX决定簇。三名先前检测的慢性肉芽肿病患者的中性粒细胞均缺乏KX。在本研究中，两名患有慢性肉芽肿病的男性同胞也被证明白细胞KX阴性，并且发现他们杂合子母亲的白细胞吸收抗KX的能力降低。已知五名患有慢性肉芽肿病的男孩缺乏KX；这种情况偶然发生的概率大于10的负6次方。
