肾上腺皮质功能在聚肌苷酸-聚胞苷酸及其组分同聚物毒性中的作用。

Role of adrenal cortical function in toxicity of polyriboinosinic-polyribocytidylic acid and its component homopolymers.

作者信息

Zedeck M S, Marquardt H, Sternberg S S, Fleisher M, Hamilton L D

出版信息

Proc Natl Acad Sci U S A. 1970 Sep;67(1):180-4. doi: 10.1073/pnas.67.1.180.

DOI:10.1073/pnas.67.1.180

PMID:5272311

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283185/

Abstract

Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic.polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.

摘要

肾上腺切除的大鼠对双链复合物聚肌苷酸-聚胞苷酸的致死作用的敏感性比正常大鼠高1000倍。皮质酮可保护它们免受这种致死作用。该复合物可迅速诱导小肠绒毛上皮的弥漫性严重坏死，而隐窝不受损伤。分别但快速连续注射单个同聚物聚肌苷酸和聚胞苷酸的致死性至少与注射复合物一样高。